Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity† †Electronic supplementary information (ESI) available: Experimental details include materials, instrumentation, synthesis and characterization, photoactivity against bacteria, transient electronic absorption spectroscopy and computational analysis. Table S1–S5 show the data of X-ray structures and DFT analysis, Fig. S1–S12 give X-ray crystal structures and dark stability of the compound, the extinction coefficients for cis-[Ru(bpy)2(INH)2]2+, HR-MS peaks for the photoproduct, the stability of the photoproduct, 1H NMR spectrum and HPLC analysis upon photoirradiation, photoactivity against bacteria and the pictures of DFT analysis. CCDC 1474453. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03028a Click here for additional data file. Click here for additional data file.
نویسندگان
چکیده
Combatting AMR: Photoactivatable Ruthenium(II)isoniazid Complex Exhibits Rapid Selective Antimycobacterial Activity† Nichola A. Smith, Pingyu Zhang, Simon E. Greenough, Michael D. Horbury, Guy Clarkson, a Daniel McFeely, Abraha Habtemariam, Luca Salassa, Vasilios G. Stavros, Christopher Dowson,* Peter J. Sadler* Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK CIC biomaGUNE, Paseo de Miramón 182, Donostia-San Sebastián, 20009, Spain Kimika Fakultatea, Euskal Herriko Unibertsitatea and Donostia International Physics Center (DIPC), P.K. 1072, Donostia-San Sebastián, 20080, Spain Ikerbasque, Basque Foundation for Science, Bilbao, 48011, Spain Current address: Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK E-mail: [email protected]; [email protected]
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School of Pharmaceutical Sciences, Southe Avenue North, Guangzhou 510515, China. E Department of Physics, The Hong Kong Un Water Bay, Kowloon, Hong Kong. E-mail: ph Guangdong Innovative Research Team, Materials and Devices, South China Unive China Department of Chemistry, State Key Labora of Molecular Functional Materials, The Technology, Clear Water Bay, Kowloon, Hon † Electronic supplementary...
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Experimental Section S3 Synthesis and Characterization of Scandium Boryl Carbene Complex (2) S4 Synthesis and Characterization of Phenylamido Enolate Complex (3) S4 13C-Labeled Experiments for Complex 3 S5 Synthesis and Characterization of Scandium Alkoxide Complex (4) S5 Synthesis and Characterization of Scandium Pyridyl Complex (5) S6 Figure S1. ORTEP drawings of 5 S6 Synthesis and Characteri...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2017